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, , K Eberlein, MD Radiotherapy Search for other works by this author on: Oxford Academic M C Jackel, MD Otorhinolaryngology, University of Göttingen, Robert Koch Strasse 40, D 37075 Göttingen, Germany Search for other works by this author on: Oxford Academic C F Hess, MD, PhD Radiotherapy Search for other works by this author on: Oxford Academic
British Journal of Radiology, Volume 74, Issue 880, 1 April 2001, Pages 368–374, https://doi.org/10.1259/bjr.74.880.740368
Published:
28 January 2014
Article history
Received:
08 December 1999
Accepted:
20 October 2000
Published:
28 January 2014
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O Pradier, K Eberlein, E Weiss, M C Jackel, C F Hess, Radiotherapy combined with simultaneous chemotherapy with mitomycin‐C and 5‐fluorouracil for inoperable head and neck cancer, British Journal of Radiology, Volume 74, Issue 880, 1 April 2001, Pages 368–374, https://doi.org/10.1259/bjr.74.880.740368
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The feasibility and effectiveness of a combined chemoradiotherapy treatment modality for locally advanced head and neck cancer was tested in a phase II trial. From March 1995 to June 1998, 35 patients with advanced squamous cell carcinoma of the head and neck were treated with a continuous intravenous infusion of 5‐fluorouracil (600 mg m−2 24 h−1 for Days 1 to 5 (120 h)) and mitomycin‐C (10 mg m−2 intravenously) on Day 5 during the first week of radiotherapy and on Day 36. 31 patients had stage IV disease; 4 patients had stage III; and 1 patient had stage II. Patient ages ranged from 42–69 years (median 56.7 years). The tumours involved were as follows: oral cavity (n=11); oropharynx (n=14); hypopharynx/larynx (n=10). Radiotherapy was delivered to a total dose of 70 Gy with conventional fractionation (2 Gy per fraction, five times a week). Chemotherapy was well tolerated and all patients received the intended dose. Mild nausea occurred in five patients. After a mean follow‐up of 21 months (range 10–44 months), 8 (23%) patients remain alive. A complete response was seen in 28 (80%) patients. When a recurrence appeared, it was within the first year after treatment. 1‐ and 2‐year overall survival rates were 46% and 23%, respectively. Grade 3 mucositis occurred in 17% of patients. Grade 1–2 thrombopaenia occurred in 3 (9%) patients, grade >2 leukopaenia in 4 (11%) patients, and grade ⪖2 anaemia in 3 (9%) patients. We observed a treatment interruption of maximum 1 week for six patients owing to mucositis. Febrile neutropaenia or aplasia were not observed. The concomitant use of 5‐fluorouracil, mitomycin‐C and radiotherapy in locally advanced head and neck carcinoma is well tolerated in this group of patients. This protocol showed good locoregional response with a very low toxicity profile.
© The British Institute of Radiology
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